
This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex| regulated alternative splicing| giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system| depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease| Pick's disease| frontotemporal dementia| cortico-basal degeneration and progressive supranuclear palsy.

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