IL12RB1 ELISA Kit (Human) (OKCD00288)

Description of target: Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade.1 Publication&#xd; &lt;p>Manually curated information for which there is published experimental evidence.&lt;/p>&#xd; &#xd; &#xd; &lt;p>&lt;a href="/manual/evidences#ECO:0000269">More…&lt;/a>&lt;/p> Manual assertion based on experiment iniRef.9"A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R."_x005F_x005F_x000D_Parham C., Chirica M., Timans J., Vaisberg E., Travis M., Cheung J., Pflanz S., Zhang R., Singh K.P., Vega F., To W., Wagner J., O'Farrell A.-M., McClanahan T.K., Zurawski S., Hannum C., Gorman D., Rennick D.M. , Kastelein R.A., de Waal Malefyt R., Moore K.W._x005F_x005F_x000D_J. Immunol. 168:5699-5708(2002) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, INTERACTION WITH IL23R. ;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: < 0.059 ng/mL