IL10RB ELISA Kit (Human) (OKCD01201)

Description of target: Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IFNL1. The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state.2 Publications&#xd; &lt;p>Manually curated information for which there is published experimental evidence.&lt;/p>&#xd; &#xd; &#xd; &lt;p>&lt;a href="/manual/evidences#ECO:0000269">More…&lt;/a>&lt;/p> Manual assertion based on experiment iniRef.9"IL-28, IL-29 and their class II cytokine receptor IL-28R."_x005F_x005F_x000D_Sheppard P., Kindsvogel W., Xu W., Henderson K., Schlutsmeyer S., Whitmore T.E., Kuestner R., Garrigues U., Birks C., Roraback J., Ostrander C., Dong D., Shin J., Presnell S., Fox B., Haldeman B., Cooper E., Taft D. , Gilbert T., Grant F.J., Tackett M., Krivan W., McKnight G., Clegg C., Foster D., Klucher K.M._x005F_x005F_x000D_Nat. Immunol. 4:63-68(2003) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, SUBUNIT.Ref.10"The expanded family of class II cytokines that share the IL-10 receptor-2 (IL-10R2) chain."_x005F_x005F_x000D_Donnelly R.P., Sheikh F., Kotenko S.V., Dickensheets H._x005F_x005F_x000D_J. Leukoc. Biol. 76:314-321(2004) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION. ;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: < 31 pg/mL