
S1PR2 encodes a member of the G protein-coupled receptors, as well as the EDG family of proteins. The encoded protein (sphingosine-1-phosphate receptor 2) is a receptor for sphingosine 1-phosphate, which participates in cell proliferation, survival, and transcriptional activation. Defects in S1PR2 have been associated with congenital profound deafness.

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