Anti-Sox-9 antibody

Sox-9 is a protein encoded by the SOX9 gene which is approximately 56,2 kDa. Sox-9 is localised to the nucleus. It is involved in signalling by wnt, cAMP signalling pathway and embryonic and induced pluripotent stem cell differentiation pathways and lineage-specific markers. It plays an important role in the normal skeletal development and may regulate the expression of other genes involved in chondrogenesis by acting as a transcription factor for these genes. Sox-9 is expressed in the nervous system, eye, bone, intestine and pancreas. Mutations in the SOX9 gene may result in campomelic dysplasia. STJ95736 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Sox-9 protein.