TLR3/ISRE Luciferase Reporter-HEK293 Cell Line

The TLR3/ISRE <a href="https://www.bosterbio.com/cells/reporter-cell-lines" style="color:#ea8d28">Luciferase cell line</a> is a stably transfected HEK 293 cell line which expresses full-length human Toll-like receptor 3 (TLR3) and Renilla luciferase reporter gene under the transcriptional control of the interferon stimulated response element (ISRE). Functional activity of the cell line has been validated by TLR3 ligand assay (Figure 1), in which upon activation by poly (I:C), TLR3 quickly initiates TRIF-dependent signaling pathway and mediates nuclear translocation of IRF3 that induces ISRE activity.The TLR3/ISRE activation by poly (I:C) is shown in Figure 1.