TIMP1 ELISA Kit (Mouse) (OKCD06478)

Description of target: TIMP1 (Tissue Inhibitor of Metalloproteinase 1), is a glycoprotein that is expressed from the several tissues of organisms. This protein is a member of the TIMP family. Using a series of somatic cell hybrids segregating translocation and deletion X chromosomes, Willard et al. (1989) mapped the TIMP locus to Xp11.4-p11.23. By linkage analysis, TIMP was found to be located about 22 cM proximal to OTC. TIMP is identical to the collagenase inhibitor. Human collagenase inhibitor (HCI) appears to play a major role in modulating the activity of interstitial collagenase as well as a number of connective tissue metalloendoproteases. Kenney et al. (2005) found that keratoconus corneas exhibited a 1.8-fold decrease in TIMP1 mRNA and a 2.8-fold decrease in protein compared with normal (physiologic) corneas.;Species reactivity: Mouse;Application: ELISA;Assay info: ;Sensitivity: < 0.059ng/mL