TIAM1 Polyclonal Antibody

Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA.,Belongs to the TIAM family.,Contains 1 DH (DBL-homology) domain.,Contains 1 PDZ (DHR) domain.,Contains 1 PH domain.,Contains 1 RBD (Ras-binding) domain.,Contains 2 PH domains.,subunit:Interacts with BAIAP2.,tissue specificity:Found in virtually all analyzed tumor cell lines including B- and T-lymphomas, neuroblastomas, melanomas and carcinomas.,