TBP ELISA Kit (Human) (OKCA02312)

Description of target: General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID . Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II . Component of a BRF2-containing transcription factor complex that regulates transcription mediated by RNA polymerase III . Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre-initiation complex) during RNA polymerase I-dependent transcription . The rate of PIC formation probably is primarily dependent on the rate of association of SL1 with the rDNA promoter. SL1 is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA.Curated;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: 11.72 pg/mL