Spike Neutralizing Antibody (Clone LxC1-G10) (SARS-CoV-2)

This human monoclonal antibody recognizes SARS-CoV-2 full-length spike proteins in both the monomeric (S1) and native trimeric conformation. This antibody has been demonstrated to cross-react with the following SARS-CoV-2 spike proteins:Wild-type Spike Trimer (BPS Bioscience #100728) Alpha B.1.1.7 Spike Trimer (BPS Bioscience #510334) Beta B.1.351 Spike Trimer (BPS Bioscience #510333) Beta B.1.351Δ242-244 Spike Trimer (BPS Bioscience #101091) Gamma P.1 Spike Trimer (BPS Bioscience #100989) Delta B.1.617.2 Spike Trimer (BPS Bioscience #101147) Delta Plus B.1.617.2.1 Spike Trimer (BPS Bioscience #101165) Wild-type S1 Protein (BPS Bioscience #100730) Delta B.1.617.2 S1 Protein (BPS Bioscience #101151) Delta Plus B.1.617.2.1 S1 Protein (BPS Bioscience #101179) Gamma P.1 S1 Protein (BPS Bioscience #101079) [Table of variants]The human ACE2 receptor is found on the surface of type I and II pneumocytes, endothelial cells, and ciliated bronchial epithelial cells. ACE2 is known to mediate COVID-19 infection through direct binding of the SARS-CoV-2 Sike protein. This neutralizing antibody has been functionally tested using BPS Bioscience Spike Trimer: ACE2 Inhibitor Screening Kits (available for purchase) .