SP140 ELISA Kit (Human) (OKCD00627)

Description of target: Component of the nuclear body, also known as nuclear domain 10, PML oncogenic domain, and KR body (PubMed:8910577). May be involved in the pathogenesis of acute promyelocytic leukemia and viral infection (PubMed:8910577). May play a role in chromatin-mediated regulation of gene expression although it does not bind to histone H3 tails (PubMed:24267382).1 Publication&#xd; &lt;p>Manually curated information that is based on statements in scientific articles for which there is no experimental support.&lt;/p>&#xd; &#xd; &#xd; &lt;p>&lt;a href="/manual/evidences#ECO:0000303">More…&lt;/a>&lt;/p> Manual assertion based on opinion iniRef.2"Identification and characterization of a leukocyte-specific component of the nuclear body."_x005F_x005F_x000D_Bloch D.B., de la Monte S.M., Guigaouri P., Filippov A., Bloch K.D._x005F_x005F_x000D_J. Biol. Chem. 271:29198-29204(1996) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SP140), VARIANT LYS-516, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION BY INTERFERON.2 Publications&#xd; &lt;p>Manually curated information for which there is published experimental evidence.&lt;/p>&#xd; &#xd; &#xd; &lt;p>&lt;a href="/manual/evidences#ECO:0000269">More…&lt;/a>&lt;/p> Manual assertion based on experiment iniRef.2"Identification and characterization of a leukocyte-specific component of the nuclear body."_x005F_x005F_x000D_Bloch D.B., de la Monte S.M., Guigaouri P., Filippov A., Bloch K.D._x005F_x005F_x000D_J. Biol. Chem. 271:29198-29204(1996) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SP140), VARIANT LYS-516, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION BY INTERFERON.Ref.6"Structure of human Sp140 PHD finger: an atypical fold interacting with Pin1."_x005F_x005F_x000D_Zucchelli C., Tamburri S., Quilici G., Palagano E., Berardi A., Saare M., Peterson P., Bachi A., Musco G._x005F_x005F_x000D_FEBS J. 281:216-231(2014) [PubMed] [Europe PMC] [Abstract]Cited for: STRUCTURE BY NMR OF 687-738, FUNCTION, PHOSPHORYLATION AT THR-726, INTERACTION WITH PIN1. ;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: < 0.053 ng/mL