S100A14 ELISA Kit (Human) (OKCD00896)

Description of target: Modulates P53/TP53 protein levels, and thereby plays a role in the regulation of cell survival and apoptosis. Depending on the context, it can promote cell proliferation or apoptosis. Plays a role in the regulation of cell migration by modulating the levels of MMP2, a matrix protease that is under transcriptional control of P53/TP53. Does not bind calcium.3 Publications&#xd; &lt;p>Manually curated information for which there is published experimental evidence.&lt;/p>&#xd; &#xd; &#xd; &lt;p>&lt;a href="/manual/evidences#ECO:0000269">More…&lt;/a>&lt;/p> Manual assertion based on experiment iniRef.5"S100A14 stimulates cell proliferation and induces cell apoptosis at different concentrations via receptor for advanced glycation end products (RAGE)."_x005F_x005F_x000D_Jin Q., Chen H., Luo A., Ding F., Liu Z._x005F_x005F_x000D_PLoS ONE 6:E19375-E19375(2011) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, INTERACTION WITH AGER.Ref.6"Involvement of S100A14 protein in cell invasion by affecting expression and function of matrix metalloproteinase (MMP)-2 via p53-dependent transcriptional regulation."_x005F_x005F_x000D_Chen H., Yuan Y., Zhang C., Luo A., Ding F., Ma J., Yang S., Tian Y., Tong T., Zhan Q., Liu Z._x005F_x005F_x000D_J. Biol. Chem. 287:17109-17119(2012) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION.Ref.7"S100A14 inhibits proliferation of oral carcinoma derived cells through G1-arrest."_x005F_x005F_x000D_Sapkota D., Costea D.E., Blo M., Bruland O., Lorens J.B., Vasstrand E.N., Ibrahim S.O._x005F_x005F_x000D_Oral Oncol. 48:219-225(2012) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION. ;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: < 0.113 ng/mL