Recombinant Human EPHB2 (611-893aa) (N-GST tag)

EPHB2 is a member of the Eph family of receptor tyrosine kinases that mediate neurodevelopmental processes such as boundary formation, axon guidance, vasculogenesis, and cell migration. EPHB2 has been shown to associate with the non-receptor tyrosine kinase Abl and activated EPHB2 causes tyrosine phosphorylation of Abl and regulates its activity . EPHB2 is overexpressed in a number of tumors particularly glioblastoma and this increases glioma cell migration and invasion .