Panobinostat

Panobinostat, also known as LBH-589, is a highly active, non-selective HDAC inhibitor. IC50's against HDAC s 1-9 range between 3 - 61 nM except for a slightly higher IC50 value of 248 nM for HDAC 8. Panobinostat inhibits tumor cell proliferation and induces apoptosis in breast cancer and T cell lymphoma cells. In addition to its tumor-suppressive activities, panobinostat induces histone H3K9 and histone H4K8 acetylation and decreases the level of c-Myc expression.