
Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. SLC22A3 is one of three similar cation transporter genes located in a cluster on chromosome 6. Solute carrier family 22 member 3 contains twelve putative transmembrane domains and is a plasma integral membrane protein.
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