LBP ELISA Kit (Human) (OKCD01112)

Description of target: Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria (PubMed:7517398, PubMed:24120359). Acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide (PubMed:7517398, PubMed:24120359).1 Publication&#xd; &lt;p>Manually curated information which has been inferred by a curator based on his/her scientific knowledge or on the scientific content of an article.&lt;/p>&#xd; &#xd; &#xd; &lt;p>&lt;a href="/manual/evidences#ECO:0000305">More…&lt;/a>&lt;/p> Manual assertion inferred by curator fromiRef.11"Structural biology of the LPS recognition."_x005F_x005F_x000D_Jerala R._x005F_x005F_x000D_Int. J. Med. Microbiol. 297:353-363(2007) [PubMed] [Europe PMC] [Abstract]Cited for: REVIEW.4 Publications&#xd; &lt;p>Manually curated information for which there is published experimental evidence.&lt;/p>&#xd; &#xd; &#xd; &lt;p>&lt;a href="/manual/evidences#ECO:0000269">More…&lt;/a>&lt;/p> Manual assertion based on experiment iniRef.2"Bactericidal/permeability-increasing protein and lipopolysaccharide (LPS)-binding protein. LPS binding properties and effects on LPS-mediated cell activation."_x005F_x005F_x000D_Wilde C.G., Seilhamer J.J., McGrogan M., Ashton N., Snable J.L., Lane J.C., Leong S.R., Thornton M.B., Miller K.L., Scott R.W._x005F_x005F_x000D_J. Biol. Chem. 269:17411-17416(1994) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION.Ref.10"CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein."_x005F_x005F_x000D_Wright S.D., Ramos R.A., Tobias P.S., Ulevitch R.J., Mathison J.C._x005F_x005F_x000D_Science 249:1431-1433(1990) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, INTERACTION WITH CD14 AND LIPOPOLYSACCHARIDE.Ref.13"Lipopolysaccharide-binding protein-mediated Toll-like receptor 4 dimerization enables rapid signal transduction against lipopolysaccharide stimulation on membrane-associated CD14-expressing cells."_x005F_x005F_x000D_Tsukamoto H., Fukudome K., Takao S., Tsuneyoshi N., Kimoto M._x005F_x005F_x000D_Int. Immunol. 22:271-280(2010) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION.Ref.14"The crystal structure of lipopolysaccharide binding protein reveals the location of a frequent mutation that impairs innate immunity."_x005F_x005F_x000D_Eckert J.K., Kim Y.J., Kim J.I., Guertler K., Oh D.Y., Sur S., Lundvall L., Hamann L., van der Ploeg A., Pickkers P., Giamarellos-Bourboulis E., Kubarenko A.V., Weber A.N., Kabesch M., Kumpf O., An H.J., Lee J.O., Schumann R.R._x005F_x005F_x000D_Immunity 39:647-660(2013) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, 3D-STRUCTURE MODELING, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, GLYCOSYLATION, VARIANT LEU-333, CHARACTERIZATION OF VARIANT LEU-333. ;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: < 1.24 ng/mL