IL11RA ELISA Kit (Human) (OKCD00445)

Description of target: Receptor for interleukin-11. The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells. Essential for the normal development of craniofacial bones and teeth. Restricts suture fusion and tooth number.1 Publication&#xd; &lt;p>Manually curated information for which there is published experimental evidence.&lt;/p>&#xd; &#xd; &#xd; &lt;p>&lt;a href="/manual/evidences#ECO:0000269">More…&lt;/a>&lt;/p> Manual assertion based on experiment iniRef.9"Inactivation of IL11 signaling causes craniosynostosis, delayed tooth eruption, and supernumerary teeth."_x005F_x005F_x000D_Nieminen P., Morgan N.V., Fenwick A.L., Parmanen S., Veistinen L., Mikkola M.L., van der Spek P.J., Giraud A., Judd L., Arte S., Brueton L.A., Wall S.A., Mathijssen I.M., Maher E.R., Wilkie A.O., Kreiborg S., Thesleff I._x005F_x005F_x000D_Am. J. Hum. Genet. 89:67-81(2011) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, VARIANTS CRSDA ARG-221; CYS-245; TRP-296 AND THR-TRP-SER-308 INS, CHARACTERIZATION OF VARIANT CRSDA TRP-296. ;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: < 0.065 ng/mL