HIF-1 alpha (Acetyl Lys532) Rabbit Polyclonal Antibody

Contains two independent C-terminal transactivation domains| NTAD and CTAD| which function synergistically. Their transcriptional activity is repressed by an intervening inhibitory domain (ID).|Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions activates the transcription of over 40 genes| including| erythropoietin| glucose transporters| glycolytic enzymes| vascular endothelial growth factor| and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization| tumor angiogenesis and pathophysiology of ischemic disease. Binds to core DNA sequence 5'-