eIF2 alpha(Phospho Ser51) Polyclonal Antibody

The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation| promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA| EIF2| and GTP. EIF2 is composed of 3 nonidentical subunits| the 36-kD EIF2-alpha subunit (EIF2S1)| the 38-kD EIF2-beta subunit (EIF2S2; MIM 603908)| and the 52-kD EIF2-gamma subunit (EIF2S3; MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al.| 1987