COL8A1 ELISA Kit (Human) (OKCD00308)

Description of target: Macromolecular component of the subendothelium. Major component of the Descemet's membrane (basement membrane) of corneal endothelial cells. Also component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis.1 Publication&#xd; &lt;p>Manually curated information for which there is published experimental evidence.&lt;/p>&#xd; &#xd; &#xd; &lt;p>&lt;a href="/manual/evidences#ECO:0000269">More…&lt;/a>&lt;/p> Manual assertion based on experiment iniRef.9"NC1 domain of human type VIII collagen (alpha 1) inhibits bovine aortic endothelial cell proliferation and causes cell apoptosis."_x005F_x005F_x000D_Xu R., Yao Z.-Y., Xin L., Zhang Q., Li T.-P., Gan R.-B._x005F_x005F_x000D_Biochem. Biophys. Res. Commun. 289:264-268(2001) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION OF VASTATIN. Vastatin, the C-terminal fragment comprising the NC1 domain, inhibits aortic endothelial cell proliferation and causes cell apoptosis.1 Publication&#xd; &lt;p>Manually curated information for which there is published experimental evidence.&lt;/p>&#xd; &#xd; &#xd; &lt;p>&lt;a href="/manual/evidences#ECO:0000269">More…&lt;/a>&lt;/p> Manual assertion based on experiment iniRef.9"NC1 domain of human type VIII collagen (alpha 1) inhibits bovine aortic endothelial cell proliferation and causes cell apoptosis."_x005F_x005F_x000D_Xu R., Yao Z.-Y., Xin L., Zhang Q., Li T.-P., Gan R.-B._x005F_x005F_x000D_Biochem. Biophys. Res. Commun. 289:264-268(2001) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION OF VASTATIN. ;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: < 0.065 ng/mL