
Bleomycin hydrolase (BMH) is a cytoplasmic cysteine peptidase that is highly conserved through evolution; however| the only known activity of the enzyme is metabolic inactivation of the glycopeptide bleomycin (BLM)| an essential component of combination chemotherapy regimens for cancer. The protein contains the signature active site residues of the cysteine protease papain superfamily.

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