AZ505 ditrifluoroacetate

AZ505 is a potent SET and MYND domain-containing 2 protein (SMYD2) inhibitor that selectively inhibits the enzymatic activity of SMYD2 (IC50: 0.12 ?M) over a variety of other protein lysine methyltransferases (IC50 > 83.3 ??), including SMYD3, DOT1L, EZH2, GLP, G9A and SET7/9 [1].