Anti-TTR antibody

TTR is a protein encoded by the TTR gene which is approximately 15,8 kDa. TTR is secreted and localised to the cytoplasm. It is involved in the innate immune system, metabolism of fat-soluble vitamins and insulin secretion. This protein is transthyretin and one of the three pre-albumins. It is a carrier protein that transports thyroid hormones in the plasma and cerebrospinal fluid and also transports retinol in the plasma. TTR is highly expressed in choroid plexus epithelial cells and in retina pigment epithelium and liver. Mutations in the TTR gene may result in familial carpal tunnel syndrome. STJ98876 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This primary antibody detects endogenous TTR protein.