Anti-TGF beta antibody

TGF-beta 1 is a protein encoded by the TGFB1 gene which is approximately 44,3 kDa. TGF-beta 1 is secreted into the extracellular space and matrix and is involved in apoptotic pathways in synovial fibroblasts, SMAD2/3 MH2 domain mutants in cancer, Th17 differentiation pathway, GPCR pathway and ERK signalling. This protein falls under the TGF-beta superfamily which bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. It is a multifunctional protein that controls proliferation, differentiation and other functions in many cell types. TGF-beta 1 is highly expressed in bone. Mutations in the TGFB1 gene may result in Camurati-Engelmann disease and Cystic Fibrosis, Renal Fibrosis. STJ95997 was developed from clone 5D2. It was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. This mouse monoclonal antibody detects endogenous levels of TGF-beta 1.