Anti-PPAR-gamma antibody

PPAR-gamma is a protein encoded by the PPARG gene which is approximately 57,6 kDa. PPAR-gamma is localised to the cytoplasm and nucleus. It is involved in regulation of lipid metabolism, gene expression, the nuclear receptor transcription pathway and AMP-activated protein kinase signalling. This protein falls under the peroxisome proliferator-activated receptor subfamily. It is a nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once logand activated, the nuclear receptor binds to DNA specific PPAR response elements and modulates the transcription of its target genes, such as acyl-CoA oxidase. PPAR-gamma has the highest expression in adipose tissue. Mutations in the PPARG gene may result in diabetes mellitus and is a cardiovascular disease risk factor. STJ95201 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of PPAR-gamma protein.