Anti-MMP-2 antibody

MMP-2 is a protein encoded by the MMP2 gene which is approximately 73,8 kDa. MMP-2 isoform 1 is secreted into the extracellular space and isoform 2 is localised to the cytoplasm and mitochondrion. It is involved in matrix metalloproteinases, degradation of the extracellular matrix, blood-brain barrier and immune cell transmigration and the integrin pathway. This protein falls under the matrix metalloproteinase gene family. It is a zinc-dependent enzyme capable of cleaving components of the extracellular matrix and molecules involved in signal transduction. It plays a role in diverse functions such as remodelling of the vasculature, angiogenesis, tissue repair, tumour invasion, inflammation and atherosclerotic plaque rupture. MMP-2 is expressed in skin fibroblasts. Mutations in the MMP2 gene may result in Winchester syndrome and Arthropathy. STJ94163 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of MMP-2 protein.