Anti-Kv2.1 antibody

Kv2.1 is a protein encoded by the KCNB1 gene which is approximately 95,8 kDa. Kv2.1 is localised to the cell membrane. It is involved in integration of energy metabolism, potassium channels and aquaporin-mediated transport. It contributes to the regulation of the action potential (AP) repolarization, duration and frequency of repetitive AP firing in neurons, muscle cells and endocrine cells and also plays a role in homeostatic attenuation of electrical excitability throughout the brain. Kv2.1 is expressed in the brain, heart, lung, liver, colon, kidney and adrenal gland. Mutations in the KCNB1 gene may result in epileptic encephalopathy. STJ93873 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Kv2.1 protein.