Anti-Human MMP-12 Antibody

MMP12, also known as macrophage elastase, is a zinc and calcium dependent endopeptidase expressed constitutively in macrophages and can be induced in monocytes. MMP12 can degrade a broad spectrum of substrates, including type IV collagen, fibronectin, laminin, vitronectin, proteoglycans, chondroitin sulfate, myelin basic protein, α-1antitrypsin, and plasminogen. It can also activate MMP2 and MMP-3. The MMP12 precursor consists of a pro domain, a catalytic domain containing the zinc-binding site, and a C-terminal hemopexin like domain.