Anti-Human Cardiotrophin-1 Antibody

Cardiotrophin1 (CT1) is a member of the cytokine family which also includes IL6, IL11, leukemia inhibitory factor (LIF), oncostatin M (OSM), and ciliary neurotrophic factor (CNTF). It was originally isolated based on its ability to induce cardiac myocyte hypertrophy in vitro. CT1 has since been shown to be a pleiotrophic cytokine with overlapping actions with other IL6 family members on a variety of cell types. Human CT1 encodes a 201 amino acid (aa) residue protein that lacks a hydrophobic signal peptide. The mechanism of CT 1 release from cells is currently not understood. Human and mouse CT1 share 80% aa sequence identity and exhibit crossspecies activity. CT1 is highly expressed in heart, skeletal muscle, liver, lung and kidney. Lower levels of CT1 expression is also seen in testis and brain. CT 1 initiates downstream signaling pathways through the heterodimerization of gp130 and the LIF receptor β subunit. A third α receptor subunit has been implicated in the receptor complex.