Anti-CD4 antibody

CD4 is a protein encoded by the CD4 gene which is approximately 51,1 kDa. CD4 is localised to the cell membrane and endoplasmic reticulum. It is involved in the TGF-beta pathway, PEDF induced signalling and the T-cell receptor signalling pathway. It is a membrane glycoprotein of T-lymphocytes that interacts with major histocompatibility complex class II antigens and is also a receptor for the human immunodeficiency virus. It initiates or augments the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. CD4 is expressed in the blood, cells of the nervous system, liver, pancreas and spleen. STJ96972 was developed from clone 11A1 and was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. This antibody detects endogenous CD4 proteins.