Anti-Caspase-4 antibody

Caspase-4 is a protein encoded by the CASP4 gene which is approximately 43,2 kDa. Caspase-4 is localised to the cytoplasm, cytosol and endoplasmic reticulum membrane. It is involved in the p53 signalling, the TRAF pathway, ceramide pathway and innate immune system. CASP4 is an essential effector of NLRP3 inflammasome-dependent CASP1 activation and IL1B and IL18 secretion in response to non-canonical activators, such as UVB radiation. It is involved in the signalling pathways of apoptosis, necrosis and inflammation. It is widely expressed, including keratinocytes and colonic and small intestinal epithelial cells. Mutations in the CASP4 gene may result in neuroblastoma. STJ92022 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Caspase-4 protein.